Partners | SysMO



SysMO was a European trans-national funding and research initiative on “Systems Biology of Microorganisms”. The goal pursued by SysMO was to record and describe the dynamic molecular processes occurring in microorganisms and to present these processes in the form of computerized mathematical models. The aim was to pool research capacities and know-how from the SysMO projects.

Each of the individual projects in SysMO were working towards different research outcomes and represented a cross-section of microorganisms, including bacteria, archaea and yeast. The environmental conditions for each organism varied widely with organisms growing in culture, soil, water and animal hosts. As a consequence of this diversity, there was no one model for experimentation or for the types of data collected and the types of models produced. In order to pool the research outcomes for SysMO, FAIRDOM – known as SysMO-DB at the time –  had to support and manage this diversity and promote a shared understanding across the community by using the same technologies.

FAIRDOM, then known as SysMo-DB supported 13 different research projects in the SysMO consortium. These were:

  • BaCell-SysMO – The transition from growing to non-growing Bacillus subtilis cells – A systems biology approach.
  • COSMIC – Systems Biology of Clostridium acetobutylicum – a possible answer to dwindling crude oil reserves.
  • SUMO – Systems Understanding of Microbial Oxygen Responses.
  • KOSMOBAC – Ion and solute homeostasis in enteric bacteria: an integrated view from the interface of modelling and experimentation.
  • SysMO-LAB – Comparative Systems Biology: Lactic Acid Bacteria.
  • PSYSMO – Systems analysis of biotech induced stresses: towards a quantum increase in process performance in the cell factory Pseudomonas putida.
  • SCaRAB – Systems Biology of a genetically engineered Pseudomonas fluorescens with inducible exo-polysaccharide production: analysis of the dynamics and robustness of metabolic networks.
  • MOSES – MicroOrganism Systems Biology: Energy and Saccharomyces cerevisiae.
  • TRANSLUCENT – Gene interaction networks and models of cation homeostasis in Saccharomyces cerevisiae.
  • STREAM – Global metabolic switching in Streptomyces coelicolor.
  • SulfoSYS – Silicon cell model for the central carbohydrate metabolism of the archaeon Sulfolobus solfataricus under temperature variation.
  • SilicoTryp – The creation of a “Silicon Trypanosome”, a comprehensive, experiment-based, multi-scale mathematical model of trypanosome physiology.
  • Noisy Strep – Unravelling how transcription fidelity and processivity influences (noisy) gene expression in the human pathogen Streptococcus pneumoniae.